The relationship between indices of hepatocellular injury and anthropometric measurements in some Babcock University Students, Ilisan, Ogun State, Nigeria

Jamiu A. Akamo, Regina N. Ugbaja, Gogonte H. Amah, Ifeoluwa Fabuluje, Joy O. Edaferiemu, Nankang G. Lepzem and Kehinde O. Oyekale

Abstract
The anthropometric measurements of some apparent healthy Babcock University students (53 male and 47 female) were investigated in this study with a view to estimating the various anthropometric parameters, blood pressure components and hepatocellular injury indices (Aspartate aminotransferase - AST, Alanine aminotransferase - ALT, and Alkaline phosphatase - ALP) in different blood groups. Blood pressure, fasting plasma glucose (FPG), AST, ALT, ALP, weight, height, unblical circumference (UC), waist circumference (WC), hip circumference (HC), were determined using standard procedures; body mass index (BMI), body fat percentage (BF%), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR) and other body composition [body surface area (BSA), fat free body mass (FFBM), fat mass, total body water (TBW), intracellular fluid (ICF), extracellular fluid (ECF)] were calculated to assess overweight and obesity. While no significant difference (p > 0.05) was observed in the age, diastolic blood pressure (DBP), heart rate, FPG, weight, BMI, BSA, UC, WC, HC and WHR values of male when compared with the female counterpart; a significant (p < 0.05) decrease was observed in BF%, fat mass and WHtR, however a significant (p < 0.05) increase was found in systolic blood pressure (SBP), pulse pressure (PP), mean arterial pressure, height, FFBM, TBW, ICF and ECF of male when compared with the female subjects. No significant difference (p > 0.05) was observed in the activities of AST, ALT and ALP of male when compared with the female counterpart. Also there was no significant difference in AST, ALT when stratified according to various ABO blood groups of both male and female subjects. A significant positive relationship was observed between the ALP and FFBM (r = 0.369, p < 0.01); and BSA (r = 0.284, p < 0.01) male. Also AST significantly correlated positively with WC (r = 0.448, p < 0.01), HC (0.292, p < 0.05), UC (r = 0.402, p < 0.05), WHR (r = 0.410, p < 0.01) and WHtR (r = 0.429, p < 0.01) in the female subjects. ALP was directly correlated significantly with fat mass (r = 0.289, p < 0.05) in the female subjects. Thus these findings in young adults suggest potential clinical utility of including WC, HC, UC, WHR, WHtR as biomarkers in liver dysfunction and cardiovascular diseases assessment formulations.

Keywords
Anthropometric measurements, Hepatocellular injury.

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