Vol. 2, No. 3, p. 17-21 - Jun. 30, 2015
Seroprevalence of hepatitis A among individuals with chronic hepatitis B infection in Isfahan Province, Iran
Parisa Shoaei, Somayeh Najafi, Laleh Zeid Abadi Nejad, Behrooz Ataei, Majid Yaran, Zary Nokhodian and Bahareh Vakili
Hepatitis A virus (HAV) is an important widespread virus and available evidences have shown that HAV superinfection with Chronic liver disease leads to more severe complications. The aim of the present study was to assess the seroepidemiology of HAV infection in patients with chronic hepatitis B in Isfahan Province, Iran in order to evaluate the necessity of vaccination for these patients. A descriptive cross-sectional study was conducted from spring 2010 to spring 2011. The target population of this study was 51 patients with chronic hepatitis B infection who had referred to diseases Infectious and Tropical Medicine Research Center of Isfahan, Iran. Subject's characteristics were collected by questionnaire. IgG anti-HAV antibody was evaluated by Enzyme-Linked Immunosorbent Assay (ELISA) and statistical analysis was done by SPSS software using descriptive statistics. The mean age of the subjects was 38 ± 14.2 years. Most of the cases were male (78.1%), 42% of CHB patients were below or equal to 30 years. The anti-HAV seropositivity was (100%) so all of the patients had a previous history of infection with HAV. According to the high HAV immunity in our study (100%), vaccination was not required in these patients. However vaccination against HAV in chronic HBV patients with anti-HAV seronegatiy may prevent super infection and development of fulminant or severe hepatitis in these patients.
Chronic Hepatitis B virus, Hepatitis A virus, Seroprevalence.
Center for Disease Control and Prevention. HBV a silent killer. 2007. Available from: <http://www.cdc.gov/ncidod/diseases/hepatitis/b/hbv silent killer>. Accessed in: Jan. 16, 2015.
Cho, H. C.; Paik, S. W.; Kim, Y. J.; Choi, M. S.; Lee, J. H.; Koh, K. C.; Yoo, B. C.; Son, H. J.; Kim, S. W. Seroprevalence of anti-HAV among patients with chronic viral liver disease. World J. Gastroenterol., v. 17, p. 236-241, 2011.
Elgouhari, H. M.; Abu-Rajab Tamimi, T. I.; Carey, W. D. Hepatitis B virus infection: understanding its epidemiology, course, and diagnosis. Cleve Clin. J. Med., v. 75, n. 12, p. 881-889, 2008.
European Association for the Study of the Liver. EASL clinical practice guidelines: Management of chronic hepatitis B virus infection. J. Hepatol., v. 57, n. 1, p. 167-185, 2012. Available from: <http://www.easl.eu/assets/application/files/ef520780b91cf4f_file. pdf>. Accessed in: Jan. 17, 2015.
Jacobsen, K. H.; Wiersma, S. T. Hepatitis A virus seroprevalence by age and world region, 1990 and 2005. Vaccine, v. 28, n. 41, p. 6653-6657, 2010.
Kim, J. I.; Kim, Y. S.; Jung, Y. K.; Kwon, O. S.; Kim, Y. S.; Ku, Y. S.; Choi, D. J.; Kim, J. H. Factors influencing the severity of acute viral hepatitis A. Korean J. Hepatol., v. 16, n. 3, p. 295-300, 2010.
Lee, S. H.; Kim, H. S.; Park, K. O.; Park, J. W.; Chun, S. Y.; Lim, S. J.; Cho, H. J.; Kim, S. J.; Park, H. W.; Moon, H. K.; Shin, W. G.; Kim, K. H.; Jang, M. K.; Lee, J. H.; Kim, H. Y. Prevalence of IgG anti-HAV in patients with chronic hepatitis B and in the general healthy population in Korea. Korean J. Hepatol., v. 16, n. 4, p. 362-368, 2010.
Merat, S.; Rezvan, H.; Nouraie, M.; Abolghasemi, H.; Jamali, R.; Amini-Kafiabad, S.; Maghsudlu, M.; Pourshams, A.; Malekzadeh, R. Seroprevalence and risk factors of hepatitis A virus infection in Iran: a population based study. Arch. Iran Med., v. 13, n. 2, p. 99-104, 2010.
Park, C. H.; Cho, Y. K.; Park, J. H.; Jun, J. S.; Park, E. S.; Seo, J. H.; Lim, J. Y. Changes in the age-specific prevalence of hepatitis A virus antibodies: a 10-year cohort study in Jinju, South Korea. Clin. Infect Dis., v. 42, n. 8, p. 1148-1150, 2006.
Poorolajal, J.; Majdzadeh, R. Prevalence of chronic hepatitis B infection in Iran: a review article. J. Res. Med. Sci., v. 14, n. 4, p. 249-258, 2009.
Roushan, M. R.; Bijani, A.; Sagheb. R.; Jazayeri, O. Prevalence of hepatitis A IgG in individuals with chronic hepatitis B infection in Babol. East Mediterr. Health J., v. 13, n. 5, p. 1108-1113, 2007.
Shavakhi, A.; Somi, M. H; Farhang, S.; Majidi, G.; Majidi, T.; Pouri, A. A. Prevalence of hepatitis A in Iranian patients with chronic liver disease. Iran J. Clin. Infect Dis., v. 3, p. 189-192, 2008.