Vol. 8, No. 18, p. 5-11 - Apr. 30, 2021
Antioxidant and colorectal anticancer potential of camel whey immunoglobulins
Lubna Abdallah
Abstract
Camel whey considered as a potent source for many different biologically active proteins. According to that, this study was aimed to find out the antioxidant and anticancer activity of the prepared camel whey immunoglobulins. The in vitro effect of the prepared whey immunoglobulins concentrations on colon cells morphology and growth was investigated by tissue culture technique. Results showed that camel whey immunoglobulins reduced colon cell viability. Moreover, the obtained results revealed that these immunoglobulins had high antioxidant activity. In conclusion, this research support the scientific evidence of camel whey proteins beneficial effects in disease therapy.
Keywords
Camel whey; Immunoglobulins; Anticancer; Antioxidant.
DOI
10.21472/bjbs(2021)081802
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References
Abd El Rahim, A. M. Antioxidant and antimicrobial activities of enzymatic hydrolysates
of camel's milk whey protein and casein. Journal of Food Dairy Sciences,
v. 11, no. 2, p. 45-50, 2020. https://doi.org/10.21608/jfds.2020.78877
Ajarem, J.; Allam, A. A.; Ebaid, H.; Maodaa, S. N.; AL-Sobeai, S. M.; Rady, A. M.;
Metwalli, A.; Altoom, N. G.; Ibrahim, K. E.; Sabri, M. I. Neurochemical, structural
and neurobehavioral evidence of neuronal protection by whey proteins in diabetic
albino mice. Behavioral and Brain Functions, v. 11, 2015. https://doi.org/10.1186/s12993-015-0053-0
Al-Ayadhi, L. Y.; Elamin, N. E. Camel milk as a potential therapy as an antioxidant
in autism spectrum disorder (ASD). Evidence-Based Complementary and Alternative
Medicine, v. 2013, Article ID 602834, 2013. https://doi.org/10.1155/2013/602834
Al-Shamsi, K. A.; Mudgil, P.; Hassan, H. M.; Maqsood, S. Camel milk protein hydrolysates
with improved technofunctional properties and enhanced antioxidant potential in in
vitro and in food model systems. Journal of Dairy Science, v. 101, no. 1,
p. 47-60, 2018. https://doi.org/10.3168/jds.2017-13194
Ayyash, M.; Al-Dhaheri, A. S.; Al Mahadin, S.; Kizhakkayil, J.; Abushelaibi, A. In
vitro investigation of anticancer, antihypertensive, antidiabetic, and antioxidant
activities of camel milk fermented with camel milk probiotic: A comparative study with
fermented bovine milk. Journal of Dairy Science, v. 101, no. 2, p. 900-911,
2018. https://doi.org/10.3168/jds.2017-13400
Badr, G.; Ramadan, N. K.; Sayed, L. H.; Badr, B. M.; Omar, H. M.; Selamoglu, Z. Why
whey? Camel whey protein as a new dietary approach to the management of free radicals
and for the treatment of different health disorders. Iranian Journal of Basic
Medical Sciences, v. 20, no. 4, p. 338-349, 2017. https://doi.org/10.22038/IJBMS.2017.8573
Brussow, H.; Hilpert, H.; Walther, I.; Siidoti, J.; Mietens, C.; Bachmann, P. Bovine
milk immunoglobulins for passive immunity to infantile rotavirus gastroenteritis.
Journal of Clinical Microbiology, v. 25, p. 982-986, 1987. https://doi.org/10.1128/jcm.25.6.982-986.1987
Cortez-Retamozo, V.; Lauwereys, M.; Hassanzadeh, G.; Gobert, M.; Conrath, K.; Muyldermans,
S.; De Baetselier, P.; Revets, H. Efficient tumor targeting by single-domain antibody
fragments of camels. International Journal of Cancer, v. 98, no. 3, p. 456-462,
2002. https://doi.org/10.1002/ijc.10212
Ebaid, H.; Badr, G.; Metwalli, A. Immunoenhancing property of dietary un-denatured whey
protein derived from three camel breeds in mice. Biologia, v. 67, p. 425-433,
2012. https://doi.org/10.2478/s11756-012-0014-0
El Sayed, I.; Ruppanner, R.; Ismail, A.; Champagne, C. P.; Assaf, R. Antibacterial and
antiviral activity of camel milk protective proteins. Journal of Dairy Science,
v. 59, p. 169-175, 1992. https://doi.org/10.1017/s0022029900030417
Evers, J. M.; Haverkamp, R. G.; Holroyd, S. E.; Jameson, G. B.; Mackenzie, D. D. S.;
McCarthy, O. J. Heterogeneity of milk fat globule membrane structure and composition
as observed using fluorescence microscopy techniques. International Dairy
Journal, v. 18, p. 1081-1089, 2008. https://doi.org/10.1016/j.idairyj.2008.06.001
Gornall, A. G.; Bardawill, C. J.; David, M. M. Determination of serum proteins by means
of the biuret reaction. Journal of Biological Chemistry, v. 177, no. 2,
p. 751-766, 1949. https://doi.org/10.1016/S0021-9258(18)57021-6
Habib, H. M.; Ibrahim, W. H.; Schneider-Stock, R.; Hassan, H. M. Camel milk lactoferrin
reduces the proliferation of colorectal cancer cells and exerts antioxidant and DNA
damage inhibitory activities. Food Chemistry, v. 141, p. 148-152, 2013.
https://doi.org/10.1016/j.foodchem.2013.03.039
Hakkak, R.; Korourian, S.; Ronis, M. J.; Johnston, J. M.; Badger, T. M. Dietary whey
protein protects against azoxymethane-induced colon tumors in male rats. Cancer
Epidemiology, Biomarkers & Prevention, v. 10, no. 5, p. 555-558, 2001.
Ibrahim, H. R.; Isono, H.; Miyata, T. Potential antioxidant bioactive peptides from
camel milk proteins. Animal Nutrition, v. 4, no. 3, p. 273-280, 2018.
https://doi.org/10.1016/j.aninu.2018.05.004
Jayanthi, P.; Lalitha, P. DPPH scavenging assay of the solvent extracts and fractionates
of Eichhornia crassipes (Mart.) Solms. Journal of Pharmacy Research, v. 5,
no. 2, p. 946-948, 2012.
Lauwereys, M.; Ghahroudi, A.; Desmyter, A. Potent enzyme inhibitors derived from dromedary
heavy-chain antibodies. The EMBO Journal, v. 17, p. 3512-3120, 1998.
https://doi.org/10.1093/emboj/17.13.3512
Low, P. P. L.; Rutherford, K. J.; Gill, H. S.; Cross, M. L. Effect of dietary whey protein
concentrate on primary and secondary antibody responses in immunized BALB/CMice.
International Immunopharmacology, v. 3, no. 3, p. 393-401, 2003. https://doi.org/10.1016/s1567-5769(02)00297-7
Papenburg, R.; Bounous, G.; Fleiszer, D.; Gold, P. Dietary milk proteins inhibit the
development of dimethylhydrazine-induced malignancy. Tumour Biology, v. 11,
p. 129-136, 1990. https://doi.org/10.1159/000217647
Sanz Fernandez, M. V.; Pearce, S. C.; Mani, V.; Gabler, N. K.; Metzger, L.; Patience, J. F.;
Rhoads, R. P.; Baumgard, L. H. Effects of dairy products on intestinal integrity in
heat-stressed pigs. Temperature, v. 1, no. 2, p. 128-134, 2014. https://doi.org/10.4161/temp.29561
Smith, C. G.; Vane, J. R. The discovery of Captopril. FASEB Journal, v. 17, p. 788-789,
2003. https://doi.org/10.1096/fj.03-0093life
Zhu, W.-W.; Kong, G.-Q.; Ma, M.-M.; Li, Y.; Huang, X.; Wang, L.-P.; Peng, Z.-Y.; Zhang, X.-H.;
Liu, X.-Y.; Wang, X.-Z. Camel milk ameliorates inflammatory responses and oxidative stress
and downregulates mitogen-activated protein kinase signaling pathways in
lipopolysaccharide-induced acute respiratory distress syndrome in rats. International
Dairy Journal, v. 99, no. 1, p. 53-56, 2016. https://doi.org/10.3168/jds.2015-10005
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