Redox balance: A probable target in the management of immune dysfunction

Babatunde Joseph Oso , Olufunke Temiloluwa Oso and Adenike Temidayo Oladiji

Abstract
Activation of cell-mediated immune is usually interconnected with the generation of oxidative species. The objective of this review was to concisely discuss the interplay between redox balance and immune functions. A qualitative review of peer reviewed papers published in journals and other publications was conducted. The review showed that cellular oxidants which act as signalling molecules could drive biological responses such as those that modulate the productions of pro- and anti-inflammatory cytokines and immune function. Moreover, beneficial effects of these cellular oxidants could be maintained by an array of defence pathways which include antioxidants, proteins and antioxidant enzymes. When there is an imbalance between increased oxidative species and suppressed antioxidant defences, oxidative stress and associated secondary complications may occur. Therefore, maintaining the redox homeostasis and immune responses through modulation of redox-sensitive inflammatory pathways may offer anticipative possibilities for management of diseases associated with dysfunctional redox homeostasis and immune disorders.

Keywords
Oxidants; Antioxidant; Phytochemicals; Immune response.

DOI
10.21472/bjbs.051006

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References
ADDC - Autoimmune Disease Coordinating Committee. Progress in Autoimmune Disease Research, 2005. Available from: <http://www.niaid.nih.gov/topics/autoimmune/Documents/adccfinal.pdf>. Accessed on: Apr. 20, 2018.

Awodele, O.; Olayemi, S. O.; Nwite, J. A.; Adeyemo, T. A. Investigation of the levels of oxidative stress parameters in HIV and HIV-TB co-infected patients. Jounal of Infection in the Developing Countries, v. 6, no. 1, p. 79-85, 2012. Available from: <http://www.jidc.org/index.php/journal/article/view/22240433>. Accessed on: Apr. 28, 2018.

Belikov, A.; Schraven, B.; Simeoni, L. T cells and reactive oxygen species. Jounal of Biomedical Science, 22:85, 2015. https://doi.org/10.1186/s12929-015-0194-3

Bhattacharyya, A.; Chattopadhyay, R.; Mitra, S.; Crowe, S. Oxidative stress: An essential factor in the pathogenesis of gastrointestinal mucosal diseases. Physiological Review, v. 94, no. 2, p. 329-354, 2012. https://doi.org/10.1152/physrev.00040.2012

Cho, Y. S.; Moon, H. The role of oxidative stress in the pathogenesis of asthma. Allergy asthma. Allergy, Asthma & Immunology Research, v. 2, no 3, p. 183-187, 2010. https://doi.org/10.4168/aair.2010.2.3.183

deVries, H. E.; Witte, M.; Hondius, D.; Rozemuller, A. J.; Drukarch, B.; Hoozemans, J.; van Horssen, J. Nrf2-induced antioxidant protection: A promising target to counteract ROS-mediated damage in neurodegenerative disease? Free Radical Biology and Medicine, v. 45, no. 10, p. 1375–1383, 2008. https://doi.org/10.1016/j.freeradbiomed.2008.09.001

Fischer, R.; Maier, O. Interrelation of oxidative stress and inflammation in neurodegenerative disease: Role of TNF. Oxidative Medicine and Cellular Longevity, v. 2015, ArticleID, 610813, 2015. https://doi.org/10.1155/2015/610813

Gil, L.; Martinez, G.; Gonzalez, I.; Alvarez, A.; Molina, R.;Tarinas, A.; Leon, O. S.; Perez J. Contribution to characterization of oxidative stress in HIV/AIDS patients. Pharmacological Research, v. 47, p. 217-224, 2003. https://doi.org/10.1016/S1043-6618(02)00320-1

Hatcher, H.; Planalp, R.; Cho, J.; Torti, F. M.; Torti, S. V. Curcumin: From ancient medicine to current clinical trials. Cellular and Molecular Life Sciences, v. 65, no. 11, p. 1631-1652, 2008. https://doi.org/10.1007/s00018-008-7452-4

Hazenberg, M. D.; Stuart, J. W.; Otto, S. A.; Borleffs, J. C.; Boucher, C. A.; de Boer, R. J.; Miedema, F.; Hamann, D. T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: A longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART). Blood, v. 95, no. 1, p. 249-255, 2000. Available from: <http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=10607709>. Accessed on: Apr. 20, 2018.

Hussain, T.; Tan, B.; Yin, Y.; Blanchier, F.;Tossou, M. C. B.; Rahu, N. Oxidative stress and inflammation: What polyphenols can do for us? Oxidative Medicine and Cellular Longevity, v. 2016, AritcleID 7432797, 2016. https://doi.org/10.1155/2016/7432797

Ichikawa, D.; Matsui, A.; Imai, M.;Sonoda, Y.; Kasahara, T. Effect of various catechins on the IL-12p40 production by murine peritoneal macrophages and a macrophage cell line, J774.1. Biological and Pharmaceutical Bulletin, v. 27, no. 9, p. 1353-1358, 2004. https://doi.org/10.1248/bpb.27.1353

Jiang, X.; Bar, H. Y.; Yan, J.; West, A. A.; Perry, C. A.; Malysheva, O. V.; Devapatla, S.; Pressman, E.; Vermeylen, F. M.; Wells, M. T.; Caudill, M. A. Pregnancy induces transcriptional activation of the peripheral innate immune system and increases oxidative DNA damage among healthy third trimester pregenant women. PloS One, v. 7, no. 11, e46736, 2012. https://doi.org/10.137/journal.pone.0046736

Johnson, J. A.; Johnson, D. A.; Kraft, A. D.; Calkins, M. J.; Jakel, R. J.; Vargas, M. R.; Chen P. C. The Nrf2-ARE pathway: An indicator and modulator of oxidative stress in neurodegeneration. Annals of New York Academy of Sciences, v. 1147, p. 61–69, 2008. https://doi.org/10.1196/annals.1427.036

Lobo, V.; Phatak, A.; Chandra, N. Free radical, antioxidants and functional foods: Impact on human health. Pharmacognosy Review, v. 4, no. 8, p. 118-126, 2010. https://doi.org/10.4103/0973-7847.70902

Lochhead, J. J.; McCaffrey, G.; Quigley, C. E.; Finch, J.; DeMarco, K. M.;Nametz, N.; Davis, T. P. Oxidative stress increases blood-brain barrier permeability and induces alterations in occluding during hypoxia-reoxygenation. Journal of Cerebral Blood Flow & Metabolism, v. 30, no. 9, p. 1625-1636, 2010. https://doi.org/10.1038/jcbfm.2010.29

Maes, M.; Yirmyia, R.; Noraberg, J.; Brene, S.; Hibbeln, J.; Perini, G.; Kubera, M.; Bob, P.; Lerer, B.; Maj, M. The inflammatory and neurodegenerative (I&ND) hypothesis of depression: Leads for future research and new drug developments in depression. Metabolic Brain Disease, v. 24, no. 1, p. 27-53, 2009. https://doi.org/10.1007/s11011-008-9118-1

Morris, G.; Maes, M. Oxidative and Nitrosative Stress and Immune-Inflammatory Pathways in Patients with Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS). Current Neuropharmacology, v. 12, no. 2, p. 168-185, 2014. https://doi.org/10.2174/1570159X11666131120224653

Oso, B. J.; Oyewo, E. B.; Oladiji, A. T. Ethanolic, n-hexane and aqueous partitioned extracts of Xylopia aethiopica fruit modulated inflammatory responses in turpentine oil induced acute inflammation in male Wistar rats. International Journal of Research Health Sciences, v. 5, no. 2, p. 1-10, 2017. Available from: <http://ijrhs.org/view_issue.php?title=Ethanolic-n-hexane-and-aqueous-partitioned-extracts-of-Xylopia-aethiopica-fruit-modulated-inflammatory-responses-in-turpentine-oil-induced-acute-inflammation-in-male-Wistar-rats>. Accessed on: Apr. 20, 2018.

Spelman, K.; Burns, J. J.; Nichols, D.; Winters, N.; Ottersberg, S.; Tenborg, M. Modulation of cytokine expression by traditional medicines: A review of herbal immunomodulators. Alternative Medicine Review, v. 11, no. 2, p. 128-150, 2006. Available from: <http://archive.foundationalmedicinereview.com/publications/11/2/128.pdf>. Accessed on: Apr. 20, 2018.

Therond, P. Oxidative stress and damages to biomolecules (lipids, proteins, DNA). Annales Pharmaceutiques Francaises, v. 64, no. 6, p. 383-389, 2006. Available from: <http://www.masson.fr/masson/MDOI-APF-11-2006-64-6-0003-4509-101019-200606807>. Accessed on: Apr. 20, 2018.

Yu, L. C.; Wang, J. T.; Wei, S. C.; Ni, Y. H. Host-microbial interactions and regulation of intestinal epithelial barrier function: From physiology to pathology. World Journal of Gastrointestinal Pathophysiology, v. 3, no. 1, p. 27-43, 2012. https://doi.org/10.4291/wjgp.v3.i1.27

Zajac, A. J.; Muller, D.; Pedersen, K.;Frelinger, J. A.; Quinn, D. G. Natural killer cell activity in lymphocytic choriomeningitis virus infected beta 2-microglobulin-deficient mice. International Immunology, v. 7, p. 1545-1556, 1995. https://doi.org/10.1093/intimm/7.10.1545