Vol. 5, No. 10, p. 259-264 - Aug. 31, 2018
Redox balance: A probable target in the management of immune dysfunction
Babatunde Joseph Oso , Olufunke Temiloluwa Oso and Adenike Temidayo Oladiji
Activation of cell-mediated immune is usually interconnected with the generation of oxidative species. The objective of this review was to concisely discuss the interplay between redox balance and immune functions. A qualitative review of peer reviewed papers published in journals and other publications was conducted. The review showed that cellular oxidants which act as signalling molecules could drive biological responses such as those that modulate the productions of pro- and anti-inflammatory cytokines and immune function. Moreover, beneficial effects of these cellular oxidants could be maintained by an array of defence pathways which include antioxidants, proteins and antioxidant enzymes. When there is an imbalance between increased oxidative species and suppressed antioxidant defences, oxidative stress and associated secondary complications may occur. Therefore, maintaining the redox homeostasis and immune responses through modulation of redox-sensitive inflammatory pathways may offer anticipative possibilities for management of diseases associated with dysfunctional redox homeostasis and immune disorders.
Oxidants; Antioxidant; Phytochemicals; Immune response.
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