Brazilian Journal of Biological Sciences (ISSN 2358-2731)

Home Archive v. 2, n. 4 (2015) Bertasoli


Vol. 2, No. 4, p. 199-207 - Dec. 31, 2015


Swine placenta and placentation

Bruno Machado Bertasoli, Amilton Cesar dos Santos, Rayan Silva de Paula, Alan S. Barbosa, Gerluza Aparecida Borges da Silva and Erika Cristina Jorge

During pregnancy the viviparous vertebrates develop a complex system of nutritional membranes surrounding the fetus. In place of the union or apposition of the fetal membranes with the uterine lining is formed the placenta. The placental types may be categorized into several complementary levels that reflect placental characteristics, being the swine placenta classified as chorioallantoic, diffuse, pleated, epitheliochorial and cross to counter-current. Structures, as the yolk sac, have function even before the appearance of the chorioallantoic placenta. The areola is also an accessory structure of the placenta, which may be found in ungulates. The extraembryonic membranes are linked intimately in the placentation, and these are important in swine early pregnancy, since the definitive placenta starts developing by the 18th day of gestation. Modifications in the swine placenta, like the presence of areolas, might have arisen as domestic species adaptions in order to supply nourishing needs during the development of concept.

Extraembryonic membranes, Gestation, Placenta, Placentation, Swine pregnancy, Swine placenta.

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Abd-Elnaeim, M. M. M.; Leiser, R.; Allen, W. R. Structural and haematological aspects of the equine placenta in mid-pregnancy. Havemeyer Foundation Monograph Series, v. 10, n. 1, p. 39-42, 2003.

Abromavich, C. The morphology and distribution of the rosettes on the foetal placenta of the pig. Anatomical Records, v. 33, n. 2, p. 67-72, 1926.

Amoroso, E. C. Placentation. In: Parkes, A. S. (Ed.). Marshall's physiology of reproduction. London: Green and Co., 1952. v. 2. p. 127-311.

Assis-Neto, A. C.; Oliveira, F. D.; Constantino, M. V. P.; Miglino, M. A. Morphology and involution of the yolk sac during early gestation bovine (Bos indicus). Acta Scientiae Veterinariae, v. 40, n. 4, p. 1-9, 2012.

Bazer, F. W. Uterine protein secretions: relationship to development of the conceptus. Journal of Animal Science, v. 41, n. 5, p. 1376-1382, 1975.

Bazer, F. W.; Vallet, J. L.; Roberts, R. M.; Sharp, D. C.; Thatcher, W. W. Role of conceptus secretory products in establishment of pregnancy. Journal of Reproduction and Fertility, v. 76, n. 2, p. 841-850, 1986.

Beaudoin, S.; Simon, L.; Simeoni, J.; Sacquin, P.; Bargy, F. Surgical approach of an early mammalian embryo: the rabbit model. Fetal Diagnosis and Therapy, v. 13, n. 2, p. 82-85, 1998.

Bertassoli, B. M.; Oliveira, F. D.; Santos, A. C.; Miglino, M. A.; Assis-Neto, A. C. Expressões gênicas nas membranas extraembrionárias e suas conexões na espécie de murina e bovina. Sabios: Revista de Saúde e Biologia, v. 7, n. 2, p. 90-101, 2012.

Bertassoli, B. M.; Santos, A. C.; Fratini, P.; Will, S. E. A. L.; Assis-Neto, A. C. Morphological analysis of the extra-embryonic membranes of domestic pig (Sus scrofa) at 20 days of gestation. Journal of Basic and Applied Research International, v. 10, n. 1, p. 14-20, 2015.

Bjorkman, N. Placentation. In: Dellman, H. D.; Brown, E. M. (Eds.). Textbook of veterinary histology. Philadelphia: Lea & Febger, 1986. p. 351-359.

Chen, T. T.; Bazer, F. W.; Gebhardt, B. M.; Roberts, R. M. Uterine secretion in mammals: synthesis and placental transport of a purple acid phosphatase in pig. Biology of Reproduction, v. 13, n. 2, p. 304-313, 1975.

Cummins, C.; Carrington, S.; Fitzpatrick, E.; Duggan, V. Ascending placentitis in the mare: a review. Irish Veterinary Journal, v. 61, n. 5, p. 307-313, 2008.

Dantzer, V.; Leiser, R. Microvasculature of regular and irregular areolae of the areola-gland subunit of the porcine placenta: structural and functional aspects. Anatomy and Embryology, v. 188, n. 2, p. 257-267, 1993.

Drieux, H.; Thiery, G. Placenttion chez les mammiferes domestiques. II. Placenta dÍs suidés. Recueil de Médecine Vétérinaire, v. 125, n. 10, p. 437-455, 1949.

Friess, A. E.; Sinowatz, F.; Skolek-Winnisch, R.; TraŁtner, W. The placenta of the pig. II. The ultrastructure of the areola. Anatomy and Embryology, v. 163, n. 1, p. 43-53, 1981.

Haar, J. L.; Ackerman, G. A. Phase and electron microscopic study of vasculogenesis and erythropoieses in the yolk sac of the mouse. The Anatomicical Records, v. 170, n. 2, p. 199-224, 1971.

Hafez, E. S. S. E.; Hafez, B. Reprodução animal. 7. ed. São Paulo: Manole, 2004.

Hitzig, W. H. Über die entwicklung der scweineplacenta. Acta Anatomica, v. 7, n. 1-2, p. 33-81, 1949.

Kauffmann, P.; Burton, G. Anatomy and genesis of the placenta. In: Knobil, E.; Neill, J. D. The physiology of reproduction. New York: Raven Press, 1994. p. 441-484.

Leiser, R.; Kauffmann. P. Placental structure: in a comparative aspect. Experimental and Clinical Endocrinology, v. 102, n. 3, p. 122-134, 1994.

Mançanares, C. A. F.; Leiser, R.; Favaron, P. O.; Carvalho, A. F.; Oliveira, V. C.; Santos, J. M.; Miglino, M. A.; Ambrósio, C. E. A Morphological analysis of the transition between the embryonic primitive intestine and yolk sac in bovine embryos and fetuses. Microscopy Research and Techniques, v. 76, n. 7, p. 756-766, 2013.

Miglino, M. A.; Pereira, F. T. V.; Santos, T. C.; Carvalho, A. F. A morfologia placentária dos suínos domésticos. Arquivos de Ciências Veterinárias e Zoologia da UNIPAR, v. 4, n. 1, p. 71-76, 2001.

Montiel, J. F.; Kaune, H.; Maliqueo, M. Maternal-fetal unit interactions and eutherian neocortical development and evolution. Frontiers in Neuroanatomy, v. 7, n. 22, p. 1-14, 2013. Available from: <>. Accessed in: Aug. 22, 2015.

Mossman, H. W. Comparative morphogenesis of the fetal membranes and accessory uterine structures. Contributions in Embriology, v. 26, n. 158, p. 133-247, 1937.

Mossman, H. W. Vertebrate fetal membranes. New Brunswick: Rutgers University Press, 1987.

Olio, R. L.; Lobo, L. M.; Pereira, M. A.; Santos, A. C.; Viana, D. C.; Favaron, P. O.; Miglino, M. A. Accessory placental structures - a review. Open Journal of Animal Sciences, v. 4, n. 5, p. 305-312, 2014. Available from: <>. Accessed in: Aug. 22, 2015.

Oliveira, G. B.; Vale, A. M.; Santos, A. C.; Moura, C. E. B.; Rocha, H. A. O.; Oliveira, M. F. Composition and significance of glycosaminoglycans in the uterus and placenta of mammals. Brazilian Archives of Biology and Technology, v. 58, n. 4, p. 512-520, 2015. Available from: <>. Accessed in: Aug. 22, 2015.

Perry, J. P. The mammalian fetal membranes. Journal of Reproduction and Fertility, v. 62, n. 2, p. 321-335, 1981.

Raub, T. J.; Bazer, F. W.; Roberts, R. M. Localization of the iron transport glycoprotein, uteroferrin, in the porcine endometrium and placenta by using immunocolloidal gold. Anatomy and Embryology, v. 171, n. 2, p. 253-258, 1985.

Roa, I.; Smok, C. S.; Pietro, G. R. Placenta: anatomia e histologia comparada. International Journal of Morphology, v. 30, n. 4, p. 1490-1496, 2012.

Santos, A. C.; Bertassoli, B. M.; Oliveira, F. D.; Assis-Neto, A. C.; Miglino, M. A. Circulação vitelina: análise comparativa. Revista Científica Eletrônica de Medicina Veterinária, v. 18, n. 2, p. 1-21, 2012. <>. Accessed in: Aug. 22, 2015.

Schwarze, E. Compêndio de anatomia veterinária: embriologia. Zaragoza: Acribia, 1970.

Schlafer, D. H.; Fisher, P. J.; Davies, C. J. The bovine placenta before and after birth: placental development and function in health and disease. Animal Reproduction Science, v. 61, n. 60, p. 145-160, 2000.

Schlosnagle, D. C.; Bazer, F. W.; Tsibris, J. C. M.; Roberts, R. M. An iron-containing phosphatase induced by progesterone in the uterine fluids of pigs. The Journal of Biological Chemistry, v. 249, n. 23, p. 7574-7579, 1974.

Steven, D. H. Placentation in mare. Journal of Reproduction and Fertility, v. 31, sup., p. 41-55, 1982.

Tommasi-Jr, H. L. P.; Santos, A. C.; Miglino, A. C.; Assis-Neto, A. C. The origin of hematopoiesis and vasculogenesis in the yolk sac and the onset of intraembryonic blood flow and cardiac function in mammalians. Revista Científica Eletrônica de Medicina Veterinária, v. 19, n. 1, p. 1-15, 2012. Available from: <>. Accessed in: Aug. 22, 2015.

Toniollo, G. H.; Vicente, W. R. R. Manual de obstetrícia veterinária. São Paulo: Varela, 1993.

Wislocki, G. B.; Dempsey, E. W. Histochemical reactions of the placenta of the pig. American Journal of Anatomy, v. 78, n. 2, p. 181-225, 1946.

Wolpert, L.; Beddington, R.; Brockes, J.; Jessell, P. L.; Meyerowitz, E. Biologia do desenvolvimento. Porto Alegre: Artes Médicas Sul, 2000.

Wooding, F. B. P.; Morgan, G.; Fowden, A. L.; Allen, W. R. Separate sites and mechanisms for placental transport of calcium, iron and glucose in the equine placenta. Placenta, v. 21, n. 7, p. 635-645, 2000.